The 2011 season for Omega Pharma–Lotto began in January with the Tour Down Under, where defending champion André Greipel debuted for the team, and ended in October at the Giro di Lombardia. As a UCI ProTeam, they were automatically invited and obligated to send a squad to every event in the UCI World Tour. The team's roster changed drastically from 2010.

The team had 28 victories in 2011, which by itself is an impressive total as it tied them with Team RadioShack and Team Sky for third-most among the major teams, behind only HTC–Highroad and Liquigas–Cannondale.