St Helens R.F.C., commonly known as Saints, is a professional rugby league club in St Helens, Merseyside, England. Founded in 1873, the club is one of the oldest members of the Rugby Football League, and one of the most successful clubs in its history. The club plays their home games at the Totally Wicked Stadium and currently compete in Super League, the top tier of British rugby league system. Since 1961 the club's home colours have been distinctive white shirts with a prominent red "V" on the chest of the jersey.

St Helens have won the League Championship 17 times, the Challenge Cup 13 times and World Club Challenge on three occasions. Since the foundation of the Super League in 1996, Saints have been the most successful team, winning 10 championships (including 4 in a row between 2019 and 2022), and being runner up a further 5 times (losing to Leeds Rhinos each time between 2007 and 2011), while winning the League Leaders Shield 9 times.

They club have a traditional rivalry with Wigan Warriors as the two most successful clubs in the British game, and close regional rivals. The clubs face each other traditionally on Good Friday. The club also have a local rivalry with the Warrington Wolves and a rivalry with Leeds Rhinos borne out of close competition during the Super League era.