Repsol Honda is the official factory team of the Honda Racing Corporation in the MotoGP class of Grand Prix motorcycle racing (World Championship road racing), backed by principal sponsor Repsol.

For 2010, the HRC Team Director was Kazuhiko Yamano, overseeing all operations including the factory teams and satellite teams. Toshiyuki Yamaji replaced Yamano as Team Manager and directed the entire Repsol Honda team. Alberto Puig was the Pedrosa Team Manager and Gianni Berti was the Dovizioso Team Manager. Shinichi Kokubu was the Grand Prix Technical Director, overseeing the six RC212V machines in MotoGP.

For 2011, Shuhei Nakamoto was HRC Vice President and directed all Honda MotoGP teams. Shinichi Kokubu was Technical Director, and Livio Suppo was HRC Communication and marketing director. Pedrosa, Dovizioso and Casey Stoner were the team riders. The team also had sponsorship from PT Astra Honda Motor, through their One Heart. and Satu Hati. brands. For 2012, Pedrosa and Stoner were the team riders. For 2013, Pedrosa continued to ride for the team while Marc Márquez was his team-mate, with Suppo as the Team Principal. The team lost their One Heart. and Satu Hati. sponsorship.

In 2014, Márquez became the youngest rider to win ten successive races in MotoGP. The team's One Heart. and Satu Hati. sponsorship returned. For 2015, Pedrosa and Márquez remained with the team. Red Bull, a long-term sponsor that was seen on the riders' helmets, became a main sponsor for the team.

Jorge Lorenzo signed a two-year deal with Repsol Honda to be a factory rider until the end of 2020 season although he retired at the end of 2019 to be replaced by Alex Márquez. He replaced Dani Pedrosa, who retired following the 2018 MotoGP season and signed with KTM for a test rider role in the succeeding years.