Honda HRC Castrol is the official factory team of Honda Racing Corporation in the MotoGP class of Grand Prix motorcycle racing (motorcycle World Championship) and is formally supported by title sponsor Repsol for a period of 30 years, until the end of 2024.

Alex Márquez replaced Jorge Lorenzo who retired at the end of 2019. Alex Márquez switched to MotoGP after becoming Moto2 World Champion in the 2019 season. Marc Márquez stayed for the 2020 season after signing a contract with Repsol Honda until the end of the 2024 season, but Márquez was replaced by Stefan Bradl after he injured his right arm at the 2020 Spanish motorcycle Grand Prix. Alex Márquez finished on the podium twice in 2020, taking two second places at the 2020 French motorcycle Grand Prix and the 2020 Aragon motorcycle Grand Prix.