Trek-Segafredo (formerly Trek Factory Racing, before that RadioShack-Nissan-Trek and before that Team Leopard-Trek is an American cycling team founded in 2010 by Luxembourg businessman Flavio Becca. The team received a UCI World Tour license from the UCI for the 2011 season. The team was presented on January 6, 2011.

On June 26, 2013, it was announced that the team would continue from 2014 with Trek as the main sponsor. This ended the uncertain period after RadioShack announced in March 2013 that it would stop sponsoring.

On December 16, 2015, it was announced that Italian coffee brand Segafredo has signed a three-year title sponsorship contract with main sponsor Trek. As of 2016, the team will therefore continue under the name Trek-Segafredo.